Question

Perform a cross between two sickle cell carriers. What ratio is obtained between carrier, disease free and diseased individuals in F₁ progeny ? Name the nitrogenous base substituted, in the haemoglobin molecule in this disease.

The pedigree chart given below represents the pattern of inheritance of thalassaemia in a family. What could be the genotype of the affected male?

A male plant, bearing red flowers, was crossed with a female plant bearing yellow flowers. In the F1 generation, all the flowers were orange in colour.

Write two closely linked genes that control α-thalassemia.

Differentiate between thalassemia and sickle cell anaemia on the basis of their effect on globin molecule of Haemoglobin.